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α-Pyrrolidinopentiophenone is a synthetic stimulant of the cathinone class developed in the 1960s that has been sold as a designer drug. Colloquially, it is sometimes called flakka. α-PVP is chemically related to pyrovalerone and is the ketone analog of prolintane..
Molar mass231.333 g/mol
Boiling point113 °C
ChemSpider ID9324063
ChEMBL Id205082
PubChem CID11148955

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Buy a-PVP Crystal. alpha-Pyrrolidinovalerophenone (also known as α-PVPA-PVPalpha-PVP, and flakka) is a novel stimulant substance of the cathinone class. α-PVP is chemically related to prolintane and belongs to a group called the substituted cathinones, which includes compounds like MDPVhexen, and a-PHP. It acts as a norepinephrine-dopamine reuptake inhibitor.

α-PVP was patented in the 1960s by Boehringer Ingelheim,. although it was never marketed. Reports of its use began to appear in the early 2010s. α-PVP has been subject to much scrutiny by the media as one of the ingredients found in “bath salts” or “legal highs” products.[. It has been mass produced in China and sold online as a research chemical.[. It has been linked to numerous hospitalizations and overdose deaths..

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User reports indicate that α-PVP produces powerful but short-lived stimulant effects comparable to those of methamphetamine and cocaine when insufflated or vaporized. Commonly reported effects include stimulationdisinhibitionincreased libidocompulsive redosing, and euphoria. Like other synthetic cathinones, α-PVP is associated with compulsive use and addiction.

Very little data exists about the pharmacological properties, metabolism, and toxicity of a-PVP. Due to its potent psychostimulant effects and unknown toxicity profile, it is highly advised to use harm reduction practices if using with this substance.


α-PVP, or alpha-Pyrrolidinovalerophenone, is a synthetic substance belonging to a group called the substituted cathinones. Substituted cathinones are derivatives of the naturally occurring substance cathinone, which is one of the psychoactive principles in khat (Catha edullis). Cathinone is composed of a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon. α-PVP’s structure consists of a cathinone core with a propyl group substituted at the alpha carbon, and a pyrrolidine ring at the amino group.

The hydrochloride salt of α-PVP is described as a white or off-white, odourless crystalline powder, with a melting point of 161.3°C. It is reported to be soluble in PBS (~10mg/ml, pH7.2), in EtOH (~20mg/ml), in DMSO (~10mg/ml) and in DMF (~3mg/ml)..


α-PVP is a potent and selective norepinephrinedopamine reuptake inhibitor (NDRI), with a similar potency as MDPV.. α-PVP does not act as a transporter substrate, i.e. it does not cause neurotransmitter release. It is a more potent inhibitor of DAT and NET than the classical stimulants cocaine and amphetamine.

Effects of MDPV, α-PVP, cocaine, and amphetamine on inhibition of [3H] transmitter uptake at dopamine (DAT), norepinephrine (NET) and serotonin (SERT) transporters[.
Compound DAT (nM) NET (nM) SERT (nM) DAT/SERT ratio
a-PVP 12.8 ± 1.2 14.2 ± 1.2 >10,000 >781
MDPV 4.1 ± 0.6 25.9 ± 5.6 3305 ± 485 806
Cocaine 211 ± 19 292 ± 34 313 ± 17 1.5
Amphetamine 93 ± 17 67 ± 16 3418 ± 314 37

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Threshold 1 – 2 mg
Light 2 – 5 mg
Common 5 – 15 mg
Strong 15 – 25 mg
Heavy 25 mg +
Total 30 – 60 minutes
Onset 20 – 60 seconds
Peak 3 – 6 minutes
Offset 15 – 30 minutes
After effects 1 – 3 hours
Threshold 0.5 – 1 mg
Light 1 – 5 mg
Common 5 – 15 mg
Strong 15 – 25 mg
Heavy 25 mg +
Total 2 – 5 hours
Onset 10 – 30 minutes
Peak 20 – 45 minutes
Offset 30 – 90 minutes
After effects 2 – 4 hours

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10g, 50g, 100g, 500g, 1kg


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